IU.V. SHMYROVA, R.B. AYU POVA, M.K. KAMANOVA, Z.B. SAKIPOVA
National University of Pharmacy, Industrial pharmacy department, Kharkiv с., Ukraine,
Kazakh National Medical University n.a. S.D. Asfendiyarov, Almaty c., Kazakstan
СOMPOSITION AND FORMULATION DEVELOPMENT OF ANTIFUNGAL SEMISOLID DOSAGE FORM
The aim of our work was elaboration of antifungal gel with Tee tree oil as an active ingredient. The obtained rheological properties give validation for using concentration as 1% of carbomer as a basis. Propylene glycol as a non aqueous solution due to its osmotic activity and penetrative properties had been chosen. Osmotic activity and pH correlate with requirements for medical application dermatological semi-solid medicine for treatment micosis. Technology for gel’s manufacture had been proposed.
Key words: semisolid dosage form, technology, antifungal activity, rhehological properties, carbomer.