UDC 616.379-008.64-053.2
N.N. Bekenov, P.Ye. Kalmenova, Sh.M. Ospanova
International Kazakh-Turkish University n.a. Kh.A. Yassavi,
Shymkent Medical Institute, Shymkent с.

USE OF ULTRA-SHORT INSULIN PREPARATION IN CHILDREN WITH TYPE 1 DIABETES MELLITUS

Modern insulin preparations are divided into groups according to origin – animal and human. The therapy with insulin of animal origin causes the formation of high levels of antibodies as well as some lipodystrophic changes in the subcutaneous fat. The use of animal insulin in children with type 1 diabetes mellitus is not able to achieve compensation for the disease. In this regard, use of ultra-short and short insulin preparations is a matter of great importance in the achievement and maintenance of this compensation for sick children with type 1 diabetes.
Purpose of the study. The purpose of the study is to assess postprandial hyperglycemia during the treatment for diabetes mellitus with ultra-short insulin preparations.
Material and methods. The study was conducted using the children’s department of Shymkent oblast endocrinology clinic. The study involved 60 children aged 5 to 12 years, who had type 1 diabetes mellitus. The children undertook insulin therapy with the bolus ultra-short preparation (Humalog) in accordance with an intensified scheme. Taking into account the level of disease compensation the children taking Humalog were divided into two groups: compensated (30) and decompensated (30).
Results and discussion. According to the data obtained from compensated children with diabetes in the group “Humalog”, the maximum rise of glycemia level after nutritional loading occurs earlier – in a half an hour after having a meal. In addition, these children have higher figures of the maximum level of glycemia. In 2 hours after nutritional loading the levels of hyperglycemia in the compensated patients met the criteria for compensation. After 2 hours after the meal glycemia in both groups exceeded a tolerant dose and reached particularly high figures in patients in the decompensated group. The study showed that postprandial glycemia figures are not a strict constant of range. The range of postprandial glycemia is influenced by many factors, primarily the state of endogenous insulin secretion. The absolute insulin deficiency inherent to type 1 diabetes mellitus contributes to an increase in the postprandial hyperglycemia level after a meal. A significant increase in glycemia levels is observed in the period of decompensation of the disease. According to our data, having a course with a fixed content of carbohydrates, as in the compensated patients described above, especially receiving ultra-short insulin preparations helps to keep the figures of postalementary glycemia within tolerable limits.
Conclusions. The ranges of postprandial glycemia depend on supplying the body with insulin. The highest level of postprandial glycemia was obtained from the decompensated patients with diabetes mellitus. The absolute insulin deficiency contributes to an increase in glycemia.
Key words: diabetes mellitus, ultra-short insulin preparations, postprandial hyperglycemia, postalimentary glycemia.

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